Table 1.
Characterization of MCI Patients
| N | Age1 Mean ± SD | Male | MMSE2 Mean ± SD | DRS3 Mean ± SD | Education Mean ± SD | APOE∈44 | Followup Months Mean ± SD5 | Crossover to AD | |
|---|---|---|---|---|---|---|---|---|---|
| Hippocampal W Score ≥0 | 13 | 79.6 ± 6.1 | 6 (46.2%) | 26.2 ± 2.3 | 127.3 ± 6.9 | 11.7 ± 3.1 | 4 (30.8%) | 42.4 ± 15.4 | 2 (15%) |
| −2.5 < Hippocampal W Score < 0 | 54 | 78.3 ± 6.4 | 23 (42.6%) | 26.7 ± 2.3 | 127.6 ± 9.4 | 13.3 ± 3.5 | 19 (35.2%) | 32.5 ± 18.4 | 19 (35%) |
| Hippocampal W Score ≤−2.5 | 13 | 73.7 ± 8.2 | 4 (30.8%) | 25.3 ± 3.4 | 126.5 ± 8.6 | 13.7 ± 3.1 | 6 (46.2%) | 23.3 ± 10.7 | 6 (46%) |
| Total | 80 | 77.7 ± 6.8 | 33 (41.25%) | 26.4 ± 2.5 | 127.4 ± 8.8 | 13.1 ± 3.4 | 9 (36.25%) | 32.6 ± 17.6 | 27 (34%) |
1
Age at time of MRI study, i.e., at time patient entered into the study
2
MMSE - Mini-Mental Status Examination score when patient entered the study. Maximum score is 30
3
Dementia Rating Scale score when patient entered the study. Maximum score is 144
4
Numbers in this column represent the number of patients in each group who were carriers of APOE genotypes which are known to confer an increased risk of AD, ∈3/4 and 4/4. Patients (n=6) with ∈2/4 were not included.
5
Followup is from time of entry into study to conversion to AD in those patients who crossed over