TABLE V.

Test of Heterogeneity of Genotype/Allele Frequencies for 13 SNPs and 3 Microsatellites Involved in DNA Repair Among Survivors of Childhood Cancer, Their Spouses, and Their Offspring

Pathway	Gene	Base change	Amino acid change	P-values (exact test)
				Survivors, spouses, and offspring	Survivors vs. spouses	Parents vs. offspring
BER	ADPRT	T → C	Val762Ala	0.962	∼1.0	0.806
	APEX	T → G	Asp148Glu	0.008a	0.001b	0.753
	hOGG1	C → G	Ser326Cys	0.120	0.458	0.079
		G → A	Arg46Gln	0.757	∼1.0	∼1.0
	XRCC1	G → A	Arg399Gln	0.598	0.444	0.564
		C → T	Arg194Trp	0.221	0.189	∼1.0
		G → A	Arg280His	0.128	0.093	∼1.0
		Microsatellite	Noncoding	0.754	0.328	0.996
NHEJ	XRCC4	T → C	Ile134Thr	0.193	0.182	∼1.0
		G → T	Ser307Ser	0.939	∼1.0	0.780
	XRCC5	Microsatellite	Noncoding	0.441	0.460	0.889
HRR	XRCC2	C → T	Pro36Ser	0.839	0.924	0.666
	XRCC3	C → T	Thr241Met	0.915	0.904	0.745
		Microsatellite	Noncoding	∼1.0	∼1.0	0.966
NER	XPD	G → A	Asp312Asn	0.142	0.685	0.051
		A → C	Lys751Gln	0.879	0.838	0.705

^aSignificant at 5% level but not after multiple test adjustment.

^bSignificant at 5% level even after multiple test adjustment.