ClustalW alignment of human α- and β-defensins. The mature peptide sequences of α- and β-defensins are aligned with the number of amino acids listed on the right. Amino acids are annotated based on the ClustalW scheme for physical characteristics: uppercase for small and hydrophobic, italic for acidic, boldface for basic, and underlined for hydroxyl, amide, and basic. Highly conserved residues in each sequence are denoted by an asterisk.