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. Author manuscript; available in PMC: 2009 Aug 21.
Published in final edited form as: Mol Ther. 2006 May 2;14(1):69–78. doi: 10.1016/j.ymthe.2006.02.018

FIG. 1.

FIG. 1

Volumes of distribution (Vd) of three substances infused into rat striatum (top) and distributed from there into the globus pallidus (bottom). Dark-shaded columns represent values for group H (high blood pressure/heart rate). Light-shaded columns represent values from group L (low blood pressure/heart rate). White columns represent values for group N (rats with no heart action). Standard deviation bars are shown on each column. Statistically significant differences in both the striatum and the globus pallidus among rats infused with the different molecules are shown as relative differences with *P < 0.009 and **P < 0.00005. Of interest is that the striatal Vd of liposomes in group H was almost identical to that of bovine serum albumin. AAV2 distribution was significantly less due to entrapment of viral capsids by heparan sulfate proteoglycan receptors widely present on neurons [20].