Table 3.
Basal gonadotropin and sex steroid concentrations in Cd and PCOSd during different Tanner stages
| Tanner I
|
Tanner II
|
Tanner III
|
Tanner IV
|
Tanner V
|
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cd (n = 20) | PCOSd (n = 30) | Cd (n = 15) | PCOSd (n = 13) | Cd (n = 19) | PCOSd (n = 21) | Cd (n = 16) | PCOSd (n = 20) | Cd (n = 14) | PCOSd (n = 15) | |
| LH (IU/liter) | 0.2 ± 0.2 | 0.4 ± 0.9 | 0.5 ± 0.7 | 0.4 ± 0.6 | 2.7 ± 2.6 | 3.0 ± 3.3 | 5.0 ± 4.7 | 6.3 ± 5.5a | 2.7 ± 2.0 | 3.7 ± 2.4 |
| FSH (IU/liter) | 2.4 ± 1.3 | 1.9 ± 0.7 | 4.2 ± 2.3 | 3.3 ± 1.9 | 6.1 ± 2.4 | 5.0 ± 2.4 | 5.8 ± 3.0 | 6.9 ± 2.1 | 5.6 ± 2.0 | 5.9 ± 1.8 |
| LH/FSH ratio | 0.1 ± 0.2 | 0.1 ± 0.1 | 0.1 ± 0.2 | 0.1 ± 0.1 | 0.4 ± 0.3 | 0.5 ± 0.4 | 0.7 ± 0.4 | 1.0 ± 0.7a | 0.6 ± 0.7 | 0.7 ± 0.4 |
| 17-OHP (ng/ml) | 0.8 ± 0.6 | 0.9 ± 0.5 | 0.6 ± 0.3 | 0.6 ± 0.2 | 0.8 ± 0.4 | 0.8 ± 0.3 | 1.0 ± 0.3 | 1.4 ± 0.7a | 1.1 ± 0.6 | 1.7 ± 0.9a |
| Androstenedione (ng/ml) | 0.4 ± 0.2 | 0.5 ± 0.3 | 0.8 ± 0.4 | 0.6 ± 0.2 | 1.2 ± 0.8 | 1.2 ± 0.5 | 1.6 ± 0.5 | 1.8 ± 1.2 | 1.6 ± 0.4 | 2.0 ± 2.1 |
| Testosterone RIA (ng/dl) | 23 ± 16 | 25 ± 14 | 29 ± 14 | 27 ± 9 | 40 ± 20 | 48 ± 19 | 41 ± 14 | 72 ± 49a | 47 ± 10 | 74 ± 36a |
| Testosterone LC-MS/MS (ng/dl) | 16 ± 8 | 15 ± 6 | 18 ± 7 | 18 ± 3 | 25 ± 13 | 28 ± 12 | 25 ± 6 | 37 ± 2a | 29 ± 5 | 40 ± 8a |
| Estradiol (pg/ml) | 9.0 ± 7.3 | 6.5 ± 2.1 | 17 ± 16 | 16 ± 13 | 30 ± 11 | 30 ± 25 | 48 ± 25 | 48 ± 48 | 41 ± 26 | 40 ± 21 |
| SHBG (nmol/liter) | 65 ± 35 | 68 ± 39 | 57 ± 44 | 71 ± 25 | 52 ± 23 | 56 ± 19 | 50 ± 22 | 31 ± 18a | 41 ± 17 | 16 ± 11a |
| FAI RIA | 2.1 ± 2.6 | 2.3 ± 3.3 | 4.3 ± 6.2 | 1.7 ± 1.5 | 3.2 ± 2.2 | 3.6 ± 2.2 | 3.2 ± 1.8 | 10 ± 8a | 4.6 ± 2.2 | 19 ± 12a |
| FAI LC-MS/MS | 1.4 ± 1.5 | 1.4 ± 1.9 | 2.6 ± 3.5 | 1.1 ± 0.9 | 2.0 ± 1.2 | 2.0 ± 1.1 | 2.0 ± 1.1 | 5.7 ± 4.5a | 2.9 ± 1.2 | 11 ± 7a |
Values are expressed as median ± sd.
a
P < 0.05 between Cd and PCOSd.