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. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Nat Immunol. 2009 Jun 28;10(8):899–906. doi: 10.1038/ni.1758

Figure 3. PGE2 reconstitutes lysosomal repair in human Mφ infected with virulent Mtb.

Figure 3

(a,b) Translocation of LAMP1, Syt-7 and mannosidase II to the surface of H37Rv-infected Mφ (MOI of 10:1) treated with forskolin (1–10 μM) (a) or PGE2 (b). (c) LAMP1 translocation induced by H37Rv in presence of PGE2 (1 μM) after addition of the specific PI3K inhibitor (LY294002, 10 μM) and/or the PKA inhibitor (KT5720, 50 nM). (d), Translocation of Syt-7, LAMP1 and mannosidase II to the surface of H37Ra-infected wild-type (WT) and Ptges−/− Mφ. The results in each panel are from one representative of three independent experiments (error bars, s.e.m.) *, p < 0.05.