TABLE 1.
Coding region variations of the β1AR and GRK5 genes. MAF, minor allele frequency
|
Gene Name
|
Common Name
|
Nucleotide
Variabilitya,b
|
Amino Acid
Variabilitya
|
MAF
|
|
|---|---|---|---|---|---|
| White | Black | ||||
| % | |||||
| ADRB1 | β1AR | 145 (A/G) | 49 (Ser/Gly) | 15 | 13 |
| ADRB1 | β1AR | 1165 (C/G) | 389 (Arg/Gly) | 27 | 42 |
| ADRB1 | β1AR | 1166 (G/T) | 389 (Arg/Leu) | <0.1 | 0.9 |
| GRK5 | GRK5 | 122 (A/T) | 41 (Gln/Leu) | 1.3 | 23 |
| GRK5 | GRK5 | 840 (G/A) | 304 (Arg/His) | <0.01 | 0 |
| GRK5 | GRK5 | 1274 (C/T) | 425 (Thr/Met) | 0 | 0.02 |
| GRK5 | GRK5 | 1624 (C/G) | 542 (Pro/Ala) | <0.01 | 0 |
a
The most common allele in a general U.S. population (composed of 12% African Americans) is the first provided.
b
Nucleotide position is relative to the AUG initiator codon.