Fig. 2.

Data for the inhibition and recovery of α7-mediated responses to the tris-AQA analogs. Each drug was tested at a concentration of 1 μM coapplied with 60 μM ACh. The filled bars are the average responses (n ≥ 4 ± S.E.M.) during the coapplications, normalized to the response to ACh alone applied 5 min earlier to the same cells; the drug was then washed out for 5 min and ACh was applied again. The open bars show the amplitude of the subsequent responses to ACh alone, normalized to the original ACh controls. The data are arranged so that the analogs are in order based on the fractional inhibition produced at the test concentration, with the most effective drugs on the left. The same order is applied to the arrangement of structures in the top of the figure.