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. 2009 Jul 15;136(16):2747–2756. doi: 10.1242/dev.033571

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Fig. 1. — Growth retardation of Gpr48 mutant mice and expression of Gpr48 in embryonic skeletal and bone cells. (A-C) Decrease in embryonic (A) and postnatal (B) body weight and long-bone length (C) in Gpr48^-/- (HO) mice. (D-J) Whole-mount lacZ staining of E12.5 (D,E) and E16.5 (F,G) wild-type (WT) (D,F) and Gpr48^+/- (E,G) mouse embryos. Tissue sections of femurs from E16.5 wild-type (H) and Gpr48^+/- (I,J) mice. The wild-type bone does not show any lacZ staining (D,F,H). (K) RT-PCR analysis of Gpr48 expression in osteoblast and chondrocyte cells, showing bone marrow stromal cell (BMSC), calvarial osteoblast (CO), osteoblast cell line MC3T3-E1, primary cultured chondrocyte (CC) and chondrocyte cell line ATDC5 with Gpr48^-/- calvarial osteoblast (CO) and chondrocyte (CC) as negative controls.