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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Biochim Biophys Acta. 2009 Mar 31;1787(11):1342–1351. doi: 10.1016/j.bbabio.2009.03.015

Figure 1.

Figure 1

(A) Schematical representation of mitochondria-ER contact sites and Ca2+ handling. Agonist stimulation induces IP3 synthesis and consequently opening of IP3R channel, which causes Ca2+ redistribution. SERCA, sercoplasmic/endoplasmic calcium ATPase; VDAC, voltage dependent anion channel; MCU, mitochondrial calcium uniporter; IP3R, IP3 receptor; (B) Combined 3D imaging of mitochondria and ER in a HeLa cell transiently expressing mtBFP(Y66H, Y145F) and erGFP(S65T) (5). (C) Rappresentative traces of ER and mitochondrial calcium response during agonist stimulation measured using specifically trageted aequorins.