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. 2009 Sep 8;7(9):e1000188. doi: 10.1371/journal.pbio.1000188

Figure 12. Model for CDK-dependent regulation of Whi5 activity and G1/S-specific transcription.

Figure 12

Shown is a schematic of the disruption of interactions between Whi5 and the HDACs, Hos3 and Rpd3, by Cln3-Cdc28 and Pcl9-Pho85-dependent phosphorylation, leading to transcription of G1 genes, including the CLN1 and CLN2 cyclins. Whi5 is then further phosphorylated by Cln1- and Cln2-Cdc28 complexes leading to complete disassembly of the Whi5-SBF complex, Whi5 nuclear export and a burst in gene expression necessary for the G1/S phase transition.