Table 3.
Predictors of symptoms and problems of the EORTC QLQ-C30 using ordinal logistic regression
| Scale | Predicting variable(s)1 | OR2 | (95% CL) | P |
|---|---|---|---|---|
| Physical function | Age (per 10 year) | 1.53 | (1.36–1.74) | <.001 |
| Sex (male vs. female) | 0.58 | (0.42–0.80) | 0.001 | |
| Active treatment (yes vs. no) | 1.87 | (1.26–2.79) | 0.002 | |
| Role function | Age (per 10 year) | 1.32 | (1.16–1.51) | <.001 |
| Diagnosis: | 0.002 | |||
| CLL | 1.01 | (0.66–1.55) | ||
| CML | 1.24 | (0.62–2.47) | ||
| AML | 1.14 | (0.56–2.31) | ||
| Hodgkin lymphoma | 1.36 | (0.67–2.78) | ||
| Non-Hodgkin lymphoma | 1.00 | – | ||
| Multiple myeloma | 3.25 | (1.86–5.67) | ||
| Other | 2.03 | (0.83–4.97) | ||
| Emotional function | No significant predictors | |||
| Social function | No significant predictors | |||
| Cognitive function | Education: | |||
| None | 1.79 | (0.94–3.42) | 0.005 | |
| Semi-skilled worker (<1 yr) | 1.23 | (0.62–2.45) | ||
| Skilled worker | 1.02 | (0.49–2.17) | ||
| Short theoretical (1–3 years) | 1.00 | – | ||
| Long theoretical (>3 years) | 0.71 | (0.40–1.28) | ||
| Academic | 0.51 | (0.24–1.08) | ||
| Age (per 10 year) | 1.18 | (1.05–1.32) | 0.006 | |
| Quality of life | Active treatment (yes vs. no) | 1.96 | (1.31–2.92) | 0.001 |
| Department: | ||||
| Haematology | 1.00 | – | 0.007 | |
| Medicine | 2.13 | (1.23–3.69) | ||
| Other | 2.43 | (0.92–6.34) | ||
| Fatigue | Active treatment (yes vs. no) | 1.85 | (1.25–2.74) | 0.002 |
| Department: | ||||
| Haematology | 1.00 | – | 0.006 | |
| Medicine | 1.82 | (1.06–3.12) | ||
| Other | 3.43 | (1.30–9.05) | ||
| Pain | Age (per 10 year) | 1.28 | (1.13–1.45) | <.001 |
| Nausea/vomiting | Contact type (hospitalised vs. out-patient) | 2.98 | (1.30–6.83) | 0.010 |
| Dyspnoea | No significant predictors | |||
| Appetite loss | Age (per 10 year) | 1.28 | (1.08–1.51) | 0.004 |
| Active treatment (yes vs. no) | 2.03 | (1.25–3.29) | 0.004 | |
| Contact type (hospitalised vs. out-patient) | 3.14 | (1.33–7.41) | 0.009 | |
| Insomnia | Sex (male vs. female) | 0.46 | (0.33–0.66) | <.001 |
| Diarrhoea | No significant predictors | |||
| Constipation | Age (per 10 year) | 1.47 | (1.22–1.78) | <.001 |
| Financial difficulties | Age (per 10 year) | 0.76 | (0.65–0.89) | <.001 |
CL, confidence limits; CLL, chronic lymphocytic leukaemia; CML, chronic myeloid leukaemia; AML, acute myeloid leukaemia.
1
Variables in the final model of the logistic regression.
2
An odds ratio above 1 reflects more functional limitations or more symptoms.