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. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Nat Struct Mol Biol. 2009 Jul 26;16(8):814–818. doi: 10.1038/nsmb.1640

Figure 4.

Figure 4

Model for MRN's functions at a mammalian DSB. Mre11 nuclease activity may resect the DNA ends for either HR or Xrcc4-independent NHEJ/MMEJ. MRN may also promote synapsis during NHEJ (and possibly during HR). “Short-range” NHEJ of repairable DSBs by MRN appears to be independent of H2A.X.