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. Author manuscript; available in PMC: 2009 Aug 24.
Published in final edited form as: Circ Res. 2009 May 7;105(3):287–294. doi: 10.1161/CIRCRESAHA.109.193995

Figure 6. Insulin regulates SREBP-1 levels in Akita mice.

Figure 6

A. Expression of SREBP-1 in nuclear extracts from atria of age-matched male WT and Akita mice determined by Western blot analysis. B. Densitometry analysis of the autoradiograph in A normalized to the expression of Gβ (*P<0.05). C. Effect of insulin treatment on SREBP-1 in atria of Akita mice. Atria of age-matched male Akita mice treated for 1 week with slow release insulin pellets or placebo pellets were homogenized as in A and the level of SREBP-1 determined by Western blot analysis. D. Mean intensity of SREBP-1 determined as in B from 4 placebo and 4 insulin treated Akita mice (*P<0.05). E. Effect of phloridzin treatment of Akita mice on levels of SREBP-1. Age-matched male Akita mice were treated with phloridzin or vehicle and SREBP-1 determined as in C. F. Mean intensity of SREBP-1 determined as in B from 7 phloridzin treated and 6 vehicle treated Akita mice.