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. Author manuscript; available in PMC: 2009 Aug 24.
Published in final edited form as: Gut. 2007 Oct 19;57(2):232–242. doi: 10.1136/gut.2006.119180

Figure 2.

Figure 2

Liver COX10 knockout (KO) phenotype. We obtained COX10 KO mice heterozygous (K1) or homozygous (K2) for the Cre transgene. K1 mice looked healthy and had a normal life span while K2 mice died at about 45–65 days of age (A) Gross phenotype of liver steatosis or “fatty liver” (pale coloration) of a 56-day-old K2 mouse compared with control. (B) Weight curves of K1 (orange circles) and K2 (red circles) mice compared with control (green squares) at different ages. Values are represented by the mean and standard deviation. (C) Histochemical analysis of control and COX10 KO mice at 56 days of age. Frozen liver sections were stained for cytochrome c oxidase (COX), COX/succinate dehydrogenase (SDH), SDH, H&E, glycogen (periodic acid–Schiff staining) and toluidine blue (TB). Scale bar for all staining is 100 μm, except for toluidine blue (25 μm).