Table.
LV Hemodynamics in WT, TNFR1−/−, and TNFR2−/− Sham and HF Mice
| WT | TNFR1−/− | TNFR2−/− | ||||
|---|---|---|---|---|---|---|
| Sham (n = 15) | HF (n = 21) | Sham (n = 7) | HF (n = 11) | Sham (n = 8) | HF (n = 15) | |
| HR | 539 ± 50 | 431 ± 49* | 519 ± 36 | 511 ± 47# | 530 ± 35 | 475 ± 53*# |
| LVPSP | 98 ± 8 | 86 ± 8* | 99 ± 10 | 96 ± 8# | 98 ± 12 | 84 ± 5*^ |
| dP/dtmax | 10245 ± 2054 | 4962 ± 1346* | 9328 ± 2084 | 7167 ± 1426*# | 9611 ± 1659 | 4997 ± 993*^ |
| dP/dtmax/IP | 185 ± 35 | 98 ± 22* | 165 ± 29 | 118 ± 19*# | 170 ± 34 | 101 ± 22*^ |
| LVEDP | 8 ± 3 | 16 ± 4* | 7 ± 1 | 12 ± 4*# | 9 ± 3$ | 8 ± 4#^ |
| Tau | 9.1 ± 2.1 | 18.8 ± 3.6* | 10.4 ± 2.9 | 14.0 ± 2.3*# | 10.4 ± 1.8 | 15.2 ± 2.8*# |
LV, left ventricular; HR, heart rate (bpm); LVPSP, LV peak systolic pressure (mm Hg); dP/dtmax, maximal rate of change in LV pressure (mm Hg/s); dP/dtmax/IP, dP/dtmax normalized fro instantaneous LV pressure (s−1); LVEDP, LV end-diastolic pressure (mm Hg); tau, time constant of LV relaxation (ms); All values mean ± SD.
*
p < 0.05 vs. respective sham,
$
p < 0.05 vs. TNFR1−/− sham,
#
p < 0.05 versus WT HF,
^
p < 0.05 vs. TNFR1−/− HF.