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. Author manuscript; available in PMC: 2010 Jan 21.
Published in final edited form as: J Am Chem Soc. 2009 Jan 21;131(2):418–419. doi: 10.1021/ja8085092

Table 1.

Conjugated addition of 6a to 5a with Cinchona Alkaloidsa

graphic file with name nihms95248t1.jpg
entry catalyst time(h) conv(%)b ee(%)c
1 1 24 0 N.D.
2 2a 24 5 47
3 2b 24 11 40
4 2c 24 40 44
5 2d 24 15 49
6 3 24 95 45
7 4a 5 >99 68
8 4b 5 >99 73
9 4c 5 >99 70
10 4d 5 >99 80
11 4e 5 >99 84
12 4f 5 >99 85
a

See Supporting Information (SI) for details,

b

Conversion was determined by 1H NMR.

c

Ee was determined by HPLC (column OD) analysis (see Supporting Information).