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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: FEMS Immunol Med Microbiol. 2008 Dec 11;55(1):55–61. doi: 10.1111/j.1574-695X.2008.00498.x

Figure 3. Inhibition of Candida albicans growth by S100A8, S100A9 and S100A8/A9 complex.

Figure 3

Recombinant S100A8, S100A9 and site-directed mutants of S100A9 were tested for their fungal growth. 10 μg/ml of S100A8 added to 10 μg/ml of wild type or mutant S100A9 was tested for their ability to inhibit fungal growth. The data indicate that substitution to alanine of either methionine 63 or 83 results in a loss of antifungal effect whereas substitution of methionine 81 does not result in the same loss of function. *p<0.01 (Single sample t-test, compared with untreated control). The data is representative of experiments conducted in triplicate a minimum of four times.