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. Author manuscript; available in PMC: 2010 Jul 1.
Published in final edited form as: J Cardiovasc Electrophysiol. 2009 Feb 27;20(7):803–810. doi: 10.1111/j.1540-8167.2009.01449.x

Figure 5.

Figure 5

Chronic amiodarone prevents the development of isoproterenol-induced delayed afterdepolarizations (DADs) and triggered activity in a pulmonary vein (PV) sleeve preparation. A: PV sleeve preparation from untreated dog: isoproterenol induces prominent DAD activity at basic cycle lengths (BCL) of 300 and 200 ms. DAD reaches threshold and induces a triggered beat followed by a DAD at a BCL of 120 ms. B: PV sleeve from chronic amiodarone-treated dog: isoproterenol fails to induce DAD activity at 300 and 200 ms and 1:1 activation failure occurs at BCL 120 ms.