Skip to main content
. Author manuscript; available in PMC: 2010 Apr 15.
Published in final edited form as: J Am Chem Soc. 2009 Apr 15;131(14):5075–5083. doi: 10.1021/ja806583y

Figure 6. Analysis of dose-dependent compound effects.

Figure 6

Heat map of assay results, focusing on the 32 most-active compounds as judged by relative dose-dependent increase (top 16) or decrease (bottom 16) of normalized assay signal. Assays are numbered on the left according to the numbering scheme in Figure 5. Heat-map data are expressed as signed log(p) values based on ChemBank scores32, with the color scheme indicated; compound ranks were determined by the dose-dependent (left-to-right) slope, using a moving average of signed log(p) values (see Methods).