Table 1.

Incidence of coronary artery inflammation and elastin breakdown in untreated and doxycycline-treated mice.

LCWE-injected	Incidence of inflammation†	Elastin breakdown‡
Untreated	21 / 28	13 / 28
Doxycycline-treated§	14 / 30*	5 / 30**

^*P = 0·0275, compared to untreated controls;

^**P = 0·0144, compared to untreated controls.

^†Incidence of inflammation is presented as the number of mice with coronary arteritis over the total number of mice injected with Lactobacillus casei cell wall extract (LCWE) at day 42.

^‡Incidence of elastin breakdown is presented as the number of mice with elastin breakdown over the total number of mice injected with LCWE at day 42.

^§Wild-type mice were treated with doxycycline in the drinking water to 30–50 mg/kg/day.