Pain behaviors to evoked mechanical and heat stimuli in rats treated with capsaicin (or vehicle) infiltration. Withdrawal threshold to the monofilaments in vehicle (n=7) treated rats (A), rats treated with 0.025% (50μg/200μl, n=8) of capsaicin (B), vehicle treated rats (n=7) (C), and 0.10% (200μg/200μl, n=8) of capsaicin (D). The results are expressed as median (horizontal line) with 1st and 3rd quartiles (boxes), and 10th and 90th percentiles (vertical lines). Inset: Diagram of the plantar aspect of the hindpaw and site of application of mechanical stimuli. Withdrawal latency in vehicle treated rats (n=8) or rats treated with 0.025% (n=8) capsaicin (E) and vehicle treated rats (n=8) or after infiltration with 0.10% (n=8) capsaicin (F). Inset: Diagram of the plantar aspect of the hindpaw and site of application of heat. The symbols represent the mean ± standard deviation (SD). Pre is before injection, 0 is 1 day after injection and before incision. hr=hours, POD=postoperative day. *P<0.05 vs vehicle.