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. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Clin Cancer Res. 2009 Jul 28;15(15):4790–4791. doi: 10.1158/1078-0432.CCR-09-0966

Figure.

Figure

Schematic showing prototypical first (black font) and second (blue font) generation CD19-specific CARs that have been expressed in (A and B) T cells and (C and D) NK cells. The chimeric signaling endodomains are shown in bold type face on purple background. Not shown are “third generation” CARs which combine CD28 and CD3-ζ endodomains with chimeric CD137 (4-1BB), as well as other co-stimulatory domains. The CARs are derived from the following references: (A)8, (B)12, (C)1, (D)9. TM = transmembrane.