Table 2.
wild-type | ΔSKIP | |
---|---|---|
Shal current density (pA/pF) | 120.23 +/− 90.93 (N=17) | 117.17 +/− 49.96 (N=18) |
Time to peak (ms) at 50 mV | 3.91 +/− 2.38 (N=16) | 2.69 +/− 1.14 (N=21) |
Steady-State Inactivation: V1/2 (mV) |
−68.15 +/− 8.00 N=14) | −68.14 +/− 7.81 (N=19) |
k (mV/e-fold shift) | 9.02 +/− 2.25 (N=14) | 8.66 +/− 1.46 (N=19) |
Tfast inactivation at 50 mV | 17.95 +/− 20.37 (N=16) | 9.86 +/− 9.75 (N=20) |
% cells Tfast < 6 ms | 25% (N=16) | 55% (N=20) |
Whole-cell voltage-clamp recordings were performed on neurons in primary cultures grown for 2–4 days after embryonic dissociation. Voltage protocols applied for analyzing times to peak, inactivation, and steady-state inactivation are described in the text. Averages, standard deviations, and number of cells (N) are shown.