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Substrate and inhibitor properties of FA with human and rat liver DHFR
| DHFR source | Km for 7,8-DHF, μM | Km for FA,* μM | Ki for FA,† μM | Ki for FA,‡ μM |
|---|---|---|---|---|
| Rat | 0.06 | 1.8 | 0.15 | 0.02 |
| Human | 0.05 | 0.5 | 0.07 | 0.01 |
*Measured over the range of 0.3 to 300 μM FA.
†Apparent Ki for FA at 7,8-DHF concentrations below 0.5 μM, where inhibition appears noncompetitive.
‡Apparent Ki for FA at 7,8-DHF concentrations above 2 μM, where inhibition appears competitive.
