| Leukemia: |
Constitutive NF-kB/Rel activation was a common finding in Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (113) B-Chronic lymphocytic leukemia (CLL) patients had constitutive high NF-kB activity (114) NF-kB in Chronic lymphocytic leukemia (CLL) was linked with fludarabine resistance (115) Rel A is an independent prognostic marker of survival in Chronic lymphocytic leukemia (CLL) and predicted the duration of response to therapy ((116) NF-kB genes were significantly associated with shorter survival of patients and seemed to be an independent prognostic factor in a multivariate analysis in T-cell lymphomas (117) NF-kB was highly predictive of Helicobacter pylori-independent status in high-grade gastric MALT lymphoma (118) NF-kB was predictive of Helicobacter pylori -independent status of low-grade gastric MALT lymphoma (119) NF-kB transcription pathway was found to be linked to overall survival of Burkitt's lymphomas patients (120) Shorter survival was associated with the expression of NF-kB-regulated genes (TRAF5, REL, and PKCA) in pts with Splenic marginal zone lymphoma (SMZL) (121) NF-kB activation was linked with the clinical and pathologic manifestations of Hodgkin's disease (122) NF-kB activity was involved in the pathogenesis of Hodgkin's disease patients (123) NF-kB pathway activation displayed the most chemoresistant response in B-cell non-Hodgkin's lymphoma (124) Constitutive activation of the noncanonical NF-kB pathway mediated the pathogenesis of multiple myeloma (27)
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| Gastrointestinal Cancers: |
Constitutive activation and differential expression of NF-kB proteins was associated with severity of oral lesions during development of oral cancer (18) NF-kB was associated with oral tumor progression and with minimal residual disease (125) NF-kB following cytotoxic chemotherapy was associated with the pathogenesis of mucositis (126) Elevated NF-kB-regulated cytokines were found in oral lichen planus patients (127) Elevated NF-kB-regulated cytokines were discovered in the saliva of patients with oral squamous cell carcinoma (128) Activated NF-kB was associated with the lack of complete pathologic response, metastases and survival in patients with esophageal carcinoma (129) NF-kB was an independent prognostic indicator of poor outcome in patients with esophageal adenocarcinoma (19) NF-kB was a major factor in the pathogenesis of ulcerative colitis (130) NF-kB overexpression was associated with the hepatocarcinogenesis induced by HBV or HCV infection (131) High expression of activated NF-kB indicates poor patient survival in pancreatic cancer (132) Nuclear colocalization of NF-kB (p50/p52) and Bcl-3, interactions mediate HCC pathogenesis (133) NF-kB activation in HCC was implicated in a poor patient outcome (134) Strong expression of NF-kB was found in patients with pancreatic cancer (135) The high NF-kB group demonstrated a shorter overall survival rate in gastric cancer (136) Nuclear expression of NF kB (1/p50) in gastric carcinoma was a prognosis biomarker (137, 138) NF-kB positivity after radiotherapy was linked with worse clinical outcome in rectal cancer (139)
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| Genitourinary Cancers: |
Nuclear expression of NF-kB was correlated with histologic grade and T category in bladder urothelial carcinoma (140) NF-KB1 promoter polymorphism is a useful marker for the identification of patients with superficial bladder cancer where the risk of recurrence is high (141) Nuclear NF-kB was linked with poor outcome in patients with prostate cancer (16) Activation of NF-kB was linked with metastasis of prostate cancer to lymph node (15) Nuclear NF-kB was strongly predictive of biochemical recurrence in patients with positive surgical margins after radical prostatectomy in prostate cancer (142) Nuclear localisation of NF-kB is an independent prognostic factor of biochemical relapse in prostate cancer (143)
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| Brain Cancers: |
Nuclear NF-kB1/p50 expression in astrocytomas was associated with tumor grade and angiogenic factors (144) Constitutive activation of NF-kB in malignant astrocytomas, especially in glioblastoma, was associated with resistance to TNF-α immunotherapy (145) Upregulation of NF-kB in human gliomas was related to tumor grade (146)
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| Breast Cancers: |
NF-kB linked gene products contributed to unusual phenotype and aggressiveness of inflammatory breast cancer (23) Increased NF-kB activity was noted in the HER-2/neu overexpressing breast cancer (147) Increased NF-kB p50 DNA-binding was prognostic biomarker in high-risk ER-positive breast cancer (148) Activated NF-kB was detected in ER-negative and ErbB2-positive breast tumors (149) NF-kB activation was a potential prognostic marker for high-risk subset of ER-positive, primary breast cancers destined for early relapse despite adjuvant endocrine therapy with tamoxifen (24)
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| Gyneoncologic Cancers: |
NF-kB (p65) expression was a significant prognostic indicator of reduced survival in ovarian cancer patients (22) Overexpression of NF-kB p65 was involved in the carcinogenesis and metastasis of ovarian cancer (150) The association of NF-kB activation with cytokine upregulation was only evident in patients with adenocarcinoma (151) The association of NF-kB activation with angiogenesis and apoptosis was evident in renal cell carcinoma (152)
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| Head & Neck Cancers: |
High levels of NF-kB (p65) was significantly higher in SCLC compared with NSCLC (21) Upregulation of NF-kB was marked in lesional advance in patients with larynx cancer (153) NF-kB expression was associated with poor prognosis in non-small-cell lung cancer patients (154) Elevated expression of NF-kB was correlated with poor clinical outcome in lung cancer patients (155) NF-kB (RelA and pIkB α-positive) was a statistically significant predictor of patient death in early stage non-small cell lung cancer (156) NF-kB was overexpressed in high-grade dysplasia and poor survival in squamous cell carcinoma of the tonsil (17) The activation of NF-kB contributed to the process of chronic obstructive pulmonary disease in humans (157)
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| Melanoma: |
NF-kB was associated with poor prognosis of human squamous cell carcinoma (158) Overexpression of NF-kB p65 played an important role in the progression of malignant melanoma (159) NF-kB p105/p50 was correlated with progression and prognosis in human melanoma patients (160)
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