Time-activity curves of [11C]MePPEP in brain from different subjects scanned for (A) 150 minutes and (B) 210 minutes. Decay-corrected measurements from the putamen (■), prefrontal cortex (□), cerebellum (●), pons (○), and white matter (x) were fitted with an unconstrained 2-tissue compartment model (−). Putamen was consistently the region of highest brain uptake. White matter was consistently the region of lowest brain uptake, followed by pons. Concentration is expressed as standardized uptake value (SUV), which normalizes for injected activity and body weight.