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. Author manuscript; available in PMC: 2010 Oct 1.

Published in final edited form as: Toxicon. 2009 Mar 25;54(5):575–582. doi: 10.1016/j.toxicon.2009.03.016

Fig. 7 — Structure of adamantane acetic acid hydroxamate (10), the most potent inhibitor of BoNT/A LC protease to date (K_I = 460 nM) and a new lead structure for inhibitor development.

11: ⁶⁰LSELDRADALQAGAS(K(Dnp))⁷⁶FE(Dpa(Mca))⁷⁹SAAKLKRKYWWKNLK⁹⁴

12: ⁶⁰LSELDDRADALQAG(Pya)⁷⁴SQ(Nop)⁷⁷ESSAAKLKRKYWWKNLK⁹⁴

Native: ⁶⁰LSELDRADALQAGASQFETSAAKLKRKYWWKNLK⁹⁴