Table 1.
Plasma Pharmacokinetic Parameters for Cocaine and Benzoylecgonine
|
Substance (mean ± SD) |
Cmax (ng/ml) |
Tmax (hr) |
AUC (0-t) (ng*h/ml) |
λz (1/hr) |
(t1/2)z (hr) |
AUC (0-∞) (ng*h/ml) |
AUCext (%) |
CL (ml/min/kg) |
Vz (l/kg) |
|
Cocaine Pre Selegiline (session 1) |
721 ± 773 | 2.66 ± 1.74 | 2640 ± 55.6 | 0.453 ± 27.9 | 1.71 ± 0.81 | 2680 ± 1470 | 1.40 ± 1.03 | 18.3 ± 6.17 | 2.49 ± 0.88 |
|
Cocaine With Selegiline (session 2) |
640 ± 332 | 2.27 ± 2.04 | 2360 ± 499 | 0.456 ± 0.09 | 1.57 ± 0.30 | 2400 ± 487 | 1.78 ± 1.87 | 18.0 ± 3.34 | 2.44 ± 0.64 |
|
Benzoyl-ecgonine Pre Selegiline (session 1) |
1045 ± 180 | 4.79 ± 0.50 | 13000 ± 3030 | 0.0928 ± 0.023 | 8.63 ± 5.36 | 13600 ± 3820 | 3.45 ± 6.45 | ||
|
Benzoyl-ecgonine With Selegiline (session 2) |
957 ± 184 | 5.04 ± 0.65 | 12900 ± 3760 | 0.0971 ± 0.024 | 7.52 ± 1.82 | 13200 ± 4180 | 2.21 ± 2.24 | ||
* Cmax = maximum plasma concentration; Tmax = time of Cmax; AUC(0-t) = area under the plasma concentration-time curve from 0 time to the time of the last measurable plasma concentration; AUC(0-∞) = area under the plasma concentration-time curve from 0 to infinity; AUCext (%) = percent of AUC(0-∞) determined by extrapolation; λz = "terminal" exponential rate constant; (t1/2)z = "terminal" exponential half-life; CL = clearance; Vz = "terminal" exponential volume of distribution; SD = standard deviation and %CV = percent coefficient of variation.