Table 4.
Measure |
Day 3–4 After Cocaine Preselegiline |
Day 4–5 0–24 hr Postselegiline |
Day 11–12 Selegiline Phase 1st Day After Cocaine▲ |
Day 12–13 Selegiline Phase 2nd Day After Cocaine† |
DAY 13–14 Selegiline Phase 3rd Day After Cocaine‡ |
PEA | 0.003 ± 0.004 | 0.132 ± 0.095* | 0.260 ± 0.171**** | 0.229 ± 0.145**** | 0.159 ± 0.104** |
MHPG-S | 1.44 ± 0.43 | 1.43 ± 0.40 | 1.09 ± 0.23** | 1.07 ± 0.40** | 1.01 ± 0.33** |
Infusion started on Day 11 at 11 AM, on day 11, 2 hours after 9 AM patch application.
▲ Selegiline patch applied @ 9 AM Day 12;
† Selegiline patch applied @ 9 AM Day 13;
‡ No selegiline patch was applied at 9 AM on Day 14.
* Changed from Day 3–4, p < 0.05
** Greater than Day 3–4, p < 0.01
*** Greater than Day 3–4, p < 0.001
**** Greater than Day 3–4, p < 0.0001