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. 2009 Aug 13;3:136–145. doi: 10.2174/1874285800903010136

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© ó (2009) NRC Canada; Licensee Bentham Open.

This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

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Fig. (6) — Simplified scheme of lysoPtdCho metabolism in Saccharomyces cerevisiae. Abbreviations are: LysoPtDCho (lysophosphatidylcholine), GroPCho (glycerophosphocholine), PtDCho (phosphatidylcholine), LPCAT (lysophosphylcholine:acyl-CoA acyltransferase), mtTaz1 (mitochondrial acyl-CoA-independent LPCAT; [25]; Plb1p, Plb2p, Plb3p (phopholipases B1, B2 and B3), Nte1p (neuropathy target esterase); Dnf1p and Dnf2p (aminophospholipid translocating P-type ATPases 1 and 2, respectively); Lem3p (noncatalytic β subunit of Dnf1p and Dnf2p); GPCAT (glycerophosphocholine acyltransferase); LRO1 (phospholipid:diacylglycerol acyltransferase; PDAT; [19, 26]; Git1P (glycerophosphoinositol/glycerophosphocholine transporter; [27]. Not shown in schematic: PLBs are also involved in the hydrolysis of PC and PI to produce extracellular glycerophosphocholine and glycerophophoinositol, respectively [28].