Table 2.
Comparison of Selected Lesions in the Cerebellum of Tg(PG14) Mice and Two Murine Scrapie Models
| Genotype | Age (days) | Neuronal apoptosis | Dendrite degeneration* | Glial-neuritic ensheathing* | Irregular neurite contours* | Dysregulation of axon-oligodendrocyte interface | Axonal inclusion | Acute terminal axon necrosis† |
|---|---|---|---|---|---|---|---|---|
| PG14+/− | 246 to 267 | ++ | + | + | ++ | + | + | − |
| PG14+/− | 361 to 394 | +++ | ++ | ++ | ++ | +++ | ++ | − |
| WT+/+ | 195 to 384 | − | − | − | − | − | +/− | − |
| ME7 scrapie | Terminal | + | − | +++ | +++ | − | + | +++ |
| in C57BL‡ | ||||||||
| 263K scrapie in | Terminal | + | − | +++ | +++ | − | +/− | +++ |
| Tg3/Prn-p0/0‡ |
−, Not detected; +/−, +, ++, +++, Single, few, several, or many examples present (see Materials and Methods for scoring details).
*
Lesions which are colocalized with PG14 PrP or PrPd.
†
Several forms of dendritic and axonal pathology are present in murine scrapie that are absent from Tg(PG14) mice. The table selects for comparison only one of these changes, an acute form of terminal axon degeneration.