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. 2009 Sep;175(3):1303–1314. doi: 10.2353/ajpath.2009.090163

Figure 1.

Figure 1

Epidermal hyperplasia, progressive hair loss, and formation of the hair follicle-derived tumors in K14-Noggin mice. A: The K14-Noggin construct used to generate transgenic mice. Western blot analysis of the 64 kDa Noggin protein in skin of 8- to 9-week-old TG versus wild-type (WT) mice. In situ hybridization: expression of transgene in basal layer of the epidermis (arrows) and HF outer root sheath (arrowheads). B: Phenotypes of 6-week-old and 6-month-old K14-Noggin mice, skin tumors are shown by arrows. C: Histological analysis of wild-type and TG skin at different time points of postnatal development by histoenzymatic alkaline phosphatase visualization. First signs of tumor development at P14 (left panel, epithelial outgrowth from the outer root sheath in TG mice is shown by arrows, inset). Formation of large HF-derived tumors at P30 (right panel, arrows). D: In 6-month-old mice, HF-derived tumors contain central cysts, multiple hair shafts (H&E staining, left panel, inset), and alkaline phosphatase-positive stroma (left panel, arrows). Morphology of human trichofolliculoma (H&E staining, right panel).