Fig. 2.

Intraperitoneal ¹³C tracer glucose tolerance test (IPGTT). Glucose ¹³C labeled fractions as per cent of total glucose in plasma (Y axis, Σm_n=C1–C6) which includes all ¹³C-labeled positional isotopomers of glucose at 0, 60, 120 and 180 min (X axis) after tracer load. Control and VPA-treated animals show virtually identical ¹³C labeled glucose fractions in plasma indicating similar absorption and clearance of tracer glucose at all time points. Control (lower continuous line) or VPA (upper broken line) glucose ¹³C-labeled plasma fractions as independent variables are compared using regression analysis to corresponding plasma cholesterol ¹³C-labeled fractions as the dependent variable to determine glucose to cholesterol flux by liver metabolism in Tables 1 and 2 (mean + standard deviation (SD); n = 8)