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Viral responses and clinical courses in a 46-year-old man with chronic hepatitis (patient 1). The underline represents sequential evolution of lamivudine- or adeforvir- resistant genotypic mutations in HBV polymerase gene. LMV: Lamivudine; ADV: Adefovir; ETV: Entecavir; ALT: Alanine aminotransferase.
