Table 1. Parameters for the basic and extended models.
Parameter | Description | Value (day-1) | References |
λ § | Rate uninfected cells restock. | 1.54 | 25 |
β § | Infection rate. | 2.31 | 3-5,7-8,10 |
δ | Uninfected cell die-off. | 0.01 | 3-5,7-8,10 |
α | Infected cell die-off. | 0.01 | 3-5,7-8,10 |
γ § | Rate infected cells are “cured” by CD4+ cells. | 6.58 | 3-5,7-8,10 |
c § | T cell responsiveness rate. | 1.86 | 24 |
σ | T cell die-off. | 0.02 | 3-5,7-8,10 |
ε § | EB† production rate from infected cells. | 2.02 | 2 |
q | Rate of EB decay. | 2.00 | 3-5,7-8,10 |
ξ*§ | Ab‡ production rate. | 0.12 | 4,9-10 |
η* | Ab decay rate. | 0.05 | 4,9-10 |
φ* § | Number of Ab consumed per disabled EB. | 5.41×10-5 | 4,9-10 |
k* | Rate EBs are disabled for each EB-Ab complex. | 0.001 | 25 |
EB = Elementary Body; ‡Ab = Antibody.
Parameters included in the extended model are indicated by (*). Parameters with (§) have been scaled to be dimensionless with respect to state variables. Scaling was based on an arbitrarily select reference category. State variable reference categories (yref, eref, zref, and uref) were the peak values (or lowest, for xref) at initial infection.