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. 2009 Sep 4;5(9):e1000568. doi: 10.1371/journal.ppat.1000568

Figure 2. L. monocytogenes within a phagosome impairs the primary T cell response.

Figure 2

Mice were infected with 1×105 CFU ActA-Lm–OVA alone, or in combination with increasing doses of LLO-Lm-OVA. 7 days later, the frequency of OVA257–264-specific CD8 T cells and LLO190–201-specific CD4 T cells was determined by pentamer and IFN-γ intracellular cytokine staining. Total splenocyte number and absolute CD8 T cells per spleen were consistent between all groups. Values in each plot represent the mean±SEM of antigen-specific cells within the CD4 or CD8 population from 5 animals per group.