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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Drug Resist Updat. 2008 Oct 31;11(6):210–218. doi: 10.1016/j.drup.2008.09.002

Fig. 2.

Fig. 2

Canonical Notch signaling pathway. Upon binding to its ligand Jagged or Delta, Notch receptor undergoes two proteolytic cleavages, the last one is mediated by γ-secretase. This leads to the release of the intracellular ICN domain which then translocates to the nucleus and binds DNA-binding protein CSL(CBF-1) displacing co-repressor complex and recruiting co-activators including MAML, thereby converting CSL from a repressor to an transcriptional activator. ICN, Notch intracellular domain; GSI, γ-secretase inhibitor; MAML, mastermind-like coactivator; CSL(CBF-1), suppressor of hairless.