Table 2.
RA neuronal attributes across hemispheres after infusion with BDNF, comparison among doses (mean ± SEM)
Vehicle controls | BDNF 0.67 mg/ml | BDNF 1.0 mg/ml | BDNF 1.5 mg/ml | Two-way repeated-measures ANOVA |
||||||
---|---|---|---|---|---|---|---|---|---|---|
Treatment |
Side |
Interaction |
||||||||
F | p | F | p | F | p | |||||
Somatic area (μm2) | 3.92 | 0.037 | 4.15 | 0.064 | 9.991 | 0.001 | ||||
Ipsilateral | 101.37 ± 6.56 | 128.94 ± 3.22 | 108.44 ± 6.83 | 132.95 ± 10.59 | ||||||
Contralateral | 103.72 ± 4.61 | 138.59 ± 1.71 | 101.04 ± 7.60 | 111.63 ± 9.16 | ||||||
Density (neurons/mm3) | 0.839 | 0.498 | 10.23 | 0.008 | 6.023 | 0.01 | ||||
Ipsilateral | 6.07 × 104 ±5.26 × 103 | 4.83 × 104 ±2.41 × 103 | 5.06 × 104 ±5.82 × 103 | 5.12 × 104 ±3.70 × 103 | ||||||
Contralateral | 5.94 × 104 ±5.34 × 103 | 4.86 × 104 ±4.44 × 103 | 5.55 × 104 ±5.46 × 103 | 6.43 × 104 ±6.86 × 103 | ||||||
Neuron number | 1.934 | 0.18 | 0.144 | 0.71 | 0.755 | 0.54 | ||||
Ipsilateral | 1.40 × 104 ±0.61 × 103 | 1.70 × 104 ±0.20 × 103 | 1.33 × 104 ±1.60 × 103 | 1.33 × 104 ±1.50 × 103 | ||||||
Contralateral | 1.38 × 104 ±0.53 × 103 | 1.73 × 104 ±1.71 × 103 | 1.26 × 104 ±0.41 × 103 | 1.49 × 104 ±1.82 × 103 |