Skip to main content
. Author manuscript; available in PMC: 2010 May 15.
Published in final edited form as: J Immunol. 2009 May 15;182(10):6160–6167. doi: 10.4049/jimmunol.0802664

FIGURE 3.

FIGURE 3

Tumor Treg suppress DC function in vitro. Splenic DC and tumor-primed CD4+ T cells were cultured alone, with tumor Treg or naïve Treg at a ratio of 1:1:1 (DC:CD4:Treg) in the presence of LPS. A. The data represents one of three independent experiments with similar results showing CD80 or CD86 expression on gated CD11c+ DC. B. IL-12 in the culture supernatant was determined by ELISA. DC/CD4 vs. DC/CD4 + tumor Treg: p<0.0005 (18h), p<0.005 (48h); DC/CD4 vs. DC/CD4 + naïve Treg: NS. The data represents three independent experiments.