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. Author manuscript; available in PMC: 2010 Jul 22.
Published in final edited form as: J Am Chem Soc. 2009 Jul 22;131(28):9767–9779. doi: 10.1021/ja9020149

Figure 1.

Figure 1

A schematic for the interaction of toxic DM1 rCUG repeats that fold into a hairpin and bind MBNL1. Modularly assembled ligands were used to inhibit the formation of the DM1 hairpin-MBNL1 complex by binding to the RNA.