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. Author manuscript; available in PMC: 2010 Jul 22.
Published in final edited form as: J Am Chem Soc. 2009 Jul 22;131(28):9767–9779. doi: 10.1021/ja9020149

Table 6. Inhibition of MBNL1-RNA11 (DM1) and RNA12(SCA3) Interactions with 5H-4. The IC50's are reported in μM.

Ligand Condition Aa Condition Ba
RNA 11 RNA 12 RNA 11 RNA 12
2 30.2 ± 6.8 48.4 ± 9.9 38.1 ± 6.9 21.1 ± 0.5
5H-4 0.25 ± 0.01 0.16 ± 0.03 0.13 ± 0.01 0.13 ± 0.06
Multivalent Enhancements b
5H-4 24 60.5 58 32
a

In condition A, 7.5 pmoles of MBNL1 are added to each well; in condition B, 2.0 pmoles of MBNL1 were added per well.

b

Calculated as described in the Experimental.