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. 2009 Jun 5;58(9):2129–2136. doi: 10.2337/db09-0117

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© 2009 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 1. — Early-phase insulin release (InsAUC_0–30/GluAUC_0–30) according to the number of risk alleles in eight insulin secretion–related SNPs (KCNJ11 rs5219, TCF7L2 rs7903146, SLC30A8 rs13266634, HHEX rs1111875, CDKN2B rs10811661, IGF2BP2 rs4402960, CDKAL1 rs7754840, and MTNR1B rs10830963). For each subject, the number of type 2 diabetes risk alleles (0, 1, 2) per SNP was weighted for their effect sizes (shown in Table 1; average effect size per risk allele among eight SNPs was 1.58, which was considered as one weighted risk allele). Effect of the number of the risk alleles on InsAUC_0–30/GluAUC_0–30 was significant (P = 9.3 × 10⁻⁴⁴, adjusted for age, BMI, and Matsuda ISI). Data are shown as means ± SE (adjusted for age, BMI, and Matsuda ISI). Bars show numbers of subjects in each category.