TABLE 1.

IL-6 alters intracellular concentrations of adenine nucleotides and creatine phosphate

	Time of incubation (min)
	Control	10	15	30	60
ATP (μmol/g tissue)	4.4 ± 0.2	3.8 ± 0.3	3.2 ± 0.3*	4.1 ± 0.4	4.1 ± 0.2†
ADP (μmol/g tissue)	0.67 ± 0.02	0.84 ± 0.04	0.73 ± 0.12	0.67 ± 0.04	0.83 ± 0.11
AMP (μmol/g tissue)	0.04 ± 0.004	0.045 ± 0.003	0.07 ± 0.006*	0.05 ± 0.007	0.03 ± 0.007†
Creatine phosphate (μmol/g tissue)	13.9 ± 0.5	10.9 ± 0.5*	10.7 ± 0.8*	12.5 ± 1.0	12.9 ± 0.4†

Data are means ± SE (n = 5-8). Rat EDL muscles were incubated with IL-6 (120 ng/ml) for 10–60 min. Because no significant differences in the nucleotide content were observed in the control muscles at the different time points, values for control muscles at all time points were pooled for statistical purposes.

*P < 0.05 vs. control,

†P < 0.05 vs. 15 min IL-6.