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. 2008 Sep 3;28(36):9055–9065. doi: 10.1523/JNEUROSCI.1424-08.2008

Figure 7.

Figure 7.

E-PS male placentas showed robust changes in expression of genes critical for growth and development signals. A, E-PS male placentas showed significant upregulation of PPARα, IGFBP-1, GLUT4, and HIF3α compared with male control placentas (*p < 0.01). In contrast, E-PS female placentas showed significant downregulation of PPARα (*p < 0.01) and a trending downregulation of IGFBP-1 (p = 0.06) compared with female control placentas. B, C, TNFα (B) and IL-6 (C) expression levels were not significantly altered by sex or E-PS (n = 5). D, In our analysis of sex differences in placental epigenetic machinery, control male placentas showed significantly lower expression of DNMT1 compared with control female placentas (# p < 0.01). E-PS increased expression of DNMT1 in female placentas (*p < 0.05). No effect of E-PS was detected in male DNMT1 levels. E, F, DNMT3a (E) and MeCP2 (F) expression levels were not significantly altered by sex or E-PS (n = 4). Data are mean ± SEM.