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Haematologic toxicity in cycle 1
| Dose level (mg) | N | Anaemia |
Neutropaenia |
Thrombocytopaenia |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Grades 1–2 | Grade 3 | Grade 4 | Grades 1–2 | Grade 3 | Grade 4 | Grades 1–2 | Grade 3 | Grade 4 | ||
| Schedule A (mg) | ||||||||||
| 15 | 2 | 1 | ||||||||
| 30 | 2 | 1 | ||||||||
| 60 | 2 | 2 | ||||||||
| 120 | 1 | |||||||||
| 240 | 4 | 1 | ||||||||
| Schedule B (mg) | ||||||||||
| 360 | 3 | 3 | ||||||||
| 540 | 6 | 3 | 1 | 1 | ||||||
| 675 | 5 | 2 | 1 | |||||||
| 850 | 7 | 3 | 1 | 2 | 1 | 2 | ||||
| 1100 | 20 | 11 | 1 | 6 | 5 | 8 | 3 | 1 | ||
| 1400 | 1 | 1 | 1 | 1 | ||||||
| Schedule C (mg) | ||||||||||
| 1600 | 5 | 1 | 2 | 1 | ||||||
| 2000 | 3 | 3 | ||||||||
| 2500 | 14 | 3 | 2 | 3 | 5 | 5 | 3 | 1 | ||
| 3200 | 6 | 1 | 1 | 2 | 4 | 1 | 1 | |||
