Table 4.

Non-haematologic toxicity in cycle 1

Dose level	N	Alopecia				Anorexia				Constipation				Diarrhoea				Fatigue				Mucositis				Nausea/Vomiting
		Grade				Grade				Grade				Grade				Grade				Grade				Grade
		1	2	3	4	1	2	3	4	1	2	3	4	1	2	3	4	1	2	3	4	1	2	3	4	1	2	3	4
Schedule A (mg)
15	2
30	2
60	2
120	1													1												1
240	4
Schedule B (mg)
360	3																	2
540	6					2												4								1
675	5	1				2												3								1
850	7		1			1	1											2	3	1		1	1			1
1100	20	9	3			3				1				3				8	2	1			2			5	2
1400	1	1																								1
Schedule C (mg)
1600	5	2																1	1			1				1
2000	3	1				1				1								1
2500	14	1				1				1								2	2							1
3200	6		1				1			3								3	1