Table.
Action potential characteristics from intact LV and RV preparations.
| LV | n | APA, mV | MDP, mV | Vmax, V/s | APD50, ms | APD90, ms | ||
|---|---|---|---|---|---|---|---|---|
| WT | 4 | 73±3 | -69±2 | 110±27 | 11±1 | 75±10 | ||
| WT, 4-AP | 4 | 76±3 | -69±2 | 107±15 | 20±1* | 77% | 84±3* | 13% |
| KChIP2-/- | 3 | 70±3 | -67±2 | 87±11 | 10±1 | 70±4 | ||
| KChIP2-/-, 4-AP | 3 | 74±6 | -67±1 | 93±5 | 21±1* | 115% | 84±2* | 21% |
| RV | n | APA, mV | MDP, mV | Vmax, V/s | APD50, ms | APD90, ms | ||
| WT | 8 | 88±2 | -77±1 | 215±12 | 4.1±0.3 | 31±3 | ||
| WT, 4-AP | 8 | 87±3 | -73±1 | 196±15 | 8.9±0.8* | 113% | 41±4* | 28% |
| KChIP2-/- | 7 | 87±2 | -77±1 | 192±20 | 3.8±0.3 | 39±4 | ||
| KChIP2-/-, 4-AP | 7 | 93±2 | -74±2 | 160±13 | 13.6±0.9*† | 262% | 53±4*† | 41% |
APA, action potential amplitude; MDP, maximal diastolic potential; Vmax, maximal upstroke velocity; APD50 and APD90, action potential duration to 50 and 90% repolarization. Relative increases in APD induced by 4-AP are indicated in percent. Pacing-cycle length: 500 ms.
*
, P<0.05 versus baseline.
†
, P<0.05 versus WT, 4-AP.