Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2009 Aug 6;5:43. doi: 10.1186/1744-8069-5-43

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2009 Capuano et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Mechanisms underlying neuron-glia interaction in trigeminal ganglia. Satellite glial cells ensheath trigeminal neurons constituting a functional unit into the trigeminal ganglion, as represented in the schematic. It has been demonstrated (dashed arrows) that trigeminal neurons release CGRP and NO within the ganglia during activation. CGRP was shown to increase IL1β secretion by trigeminal satellite cells (dashed arrows). Thus, IL-1β and the NO donor DETA/NO (red) were tested on satellite cells. DETA/NO better mimics neuronal NO release generated by nNOS. Both stimuli increase glial COX activity, even though via different molecular mechanisms (arrows). Conditioned media harvested from glial cells challenged with both stimuli promote neuronal sensitization. Compounds exogenously added to trigeminal satellite cells in different experimental paradigms are indicated in red.