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Model depicting the signaling pathways and feedback mechanisms that regulate PAI1 expression. Factors that were correlated with PAI1 expression in all three breast cancer data sets are highlighted in bold. FN1 is included because it is coregulated in parallel with PAI1 by TGFβ and CTGF (31). *, factors that have been shown to promote PAI1 expression in culture (21, 22, 28, 30).
